Fructose and metabolic diseases: too much to be good…

“Fructose and metabolic diseases: too much to be good…”
“Published Online: 29 August 2021”
“Excessive consumption of fructose, the sweetest of all naturally occurring carbohydrates, has been linked to worldwide epidemics of metabolic diseases in humans, and it is considered an independent risk factor for cardiovascular diseases. We provide an overview about the features of fructose metabolism, as well as potential mechanisms by which excessive fructose intake is associated with the pathogenesis of metabolic diseases both in humans and rodents.”

In the past decades, dietary patterns have changed remarkably. In conjunction with the advent of sedentary lifestyles in both industrialized and developing countries, this trend of changing dietary patterns is highly associated with the increasing epidemic of obesity, non-alcoholic fatty liver disease (NAFLD), type 2 diabetes, and metabolic syndrome.”

“The rapid increase in .. obesity and NAFLD has become one of the major public health concerns globally. Sugars in the form of sucrose (half fructose) or high-fructose corn syrup (HFCS, about 45-55% fructose) are major sweeteners added in food and beverages, which comprise a large proportion of the modern diet..”

“It is well recognized that excessive consumption of added sugars is a risk factor for cardiometabolic diseases, and has been a big public health problem.[5,6] Therefore, recommendations for the restriction of sugar consumption attract significant attention. As the major component of added sugar, fructose is a monosaccharide with a similar formulary to glucose. However, its metabolism pathway is quite different from glucose in vivo.”
“There is substantial evidence that excessive fructose intake has detrimental effects on multiple metabolic diseases. It causes visceral fat accumulation and leads to obesity, hyperlipidemia, insulin resistance, hypertension, and hyperuricemia, which are associated with development of diabetes, fatty liver disease, cardiovascular disease..”

“Even for those in the “normal” range of fructose consumption, fructose can still rapidly impair intermediate physiological endpoints like circulating lipids and insulin sensitivity in humans. Therefore, further understanding fructose metabolism and its role in the development of metabolic diseases will provide fundamental insights into pathogenic mechanisms, which assists to develop new diagnostic, preventative, and therapeutic strategies for metabolic disease.”



493920cookie-checkFructose and metabolic diseases: too much to be good…
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